Term: Anti-thrombogenic Coating

Category: Coatings

Definition: Anti-thrombogenic coatings are surface coatings that are meant to enhance the hemocompatibility of blood-contacting medical devices. These coatings minimize thrombosis (blood clot formation). They improve the safety, efficacy, and long-term use of medical devices after minimizing the activation of the body’s coagulation pathways in the context of cardiovascular and extracorporeal use.

How They Work: anti-thrombogenic coatings create a smooth, biocompatible layer on medical devices to stop clots from forming. They do this by keeping the surface hydrated, blocking protein and cell buildup, and using anticoagulants (such as heparin) that prevent blood platelets from sticking together.

Common Uses:

• Vascular stents, grafts, and catheters
• Hemodialysis and cardiopulmonary bypass circuits
• Artificial heart valves and ventricular assist devices
• Blood oxygenators and extracorporeal membranes
• Long-term implantable sensors and tubing systems

Related Content and Resources: 

Thromboresistant Medical Device Coatings

The Importance and Benefits of Thromboresistant Coatings

Hydrophilic Coatings for Medical Devices: Intro, Benefits & Uses